Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Endothelin Receptor - BMS 182874

BMS 182874

CAS No. 153042-42-3

BMS 182874( —— )

Catalog No. M34185 CAS No. 153042-42-3

BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for ETA.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 103 Get Quote
5MG 155 Get Quote
10MG 250 Get Quote
25MG 419 Get Quote
50MG 596 Get Quote
100MG 803 Get Quote
500MG 1638 Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    BMS 182874
  • Note
    Research use only, not for human use.
  • Brief Description
    BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for ETA.
  • Description
    BMS 182874 is an orallyactive, highly selective endothelin receptor (ETA receptor) antagonist, with IC50 value of 0.150 μM, Ki of 0.055 μM. BMS 182874 reduces the arterial pressure of Deoxycorticosterone acetate (HY-B1472) induced hypertension model in rats, and can be used for cardiovascular disease research.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Kidney Deoxycorticosterone acetate -salt hypertensive rats Dosage:100 μM/kg Administration:Oral gavage (p.o.); Intravenous injection (i.v.)Result:Made arterial pressure slowly fell by 25% from a control level. After dosing for 12 and 24 h, makes arterial pressure is still 12% below the control level.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Endothelin Receptor
  • Recptor
    Endothelin Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    153042-42-3
  • Formula Weight
    345.42
  • Molecular Formula
    C17H19N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    S(NC1=C(C)C(C)=NO1)(=O)(=O)C=2C3=C(C(N(C)C)=CC=C3)C=CC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Abdullaha M, et.al. Methoxy-naphthyl-Linked N-Benzyl Pyridinium Styryls as Dual Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Structure-Activity Relationship. ACS Omega. 2023 May 9;8(20):17591-17608. ?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • BMS 182874

    BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for ETA.

  • Nebentan potassium

    Nebentan potassium (YM598) is an orally active and selective nonpeptide endothelin receptor (ETA receptor) antagonist.

  • Zibotentan

    Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.

Sign In Join Free